Hip-hop veterans Method Man and Redman will perform together at 10 p.m. Tuesday at House of Blues. Several opening acts will precede the duo’s set, including B-Real of west coast hip-hop outfit Cypress Hill and breakthrough Chicago rapper Mick Jenkins. Meth & Red’s chemistry has not only featured the musical creation of both volumes of “Blackout!,” but also a brief foray into the realm of comedy, both in a televised setting and on the big screen. Their collaborations have extended into work with artists such as Tupac and D’Angelo.

Both rappers found success with separate endeavors before the melding of their lucrative partnership. Method Man joined the Wu-Tang Clan in the ’90s and he gained significant exposure in the music industry with his eponymous solo track that appeared on their legendary debut “Enter the Wu-Tang (36 Chambers).” He was also the first member of the hip-hop collective to release a solo album titled “Tical,” which receiveD critical acclaim as a hip-hop classic. His most recent musical development is his involvement with the upcoming Wu-Tang album, “A Better Tomorrow,” which is set to be released on Dec. 2.

Redman, meanwhile, has maintained a steady stream of musical output since the release of his “Whut? TheeAlbum” in 1992, which was heralded for its funk-based production and Red’s humorous punchlines. His first exposure to the music industry was his appearance on the classic EPMD album, “Business as Usual.” Currently, Redman is working on a sequel to his 1996 album “Muddy Waters,” as well as developing the third volume of “Blackout!” with his east coast cohort.